Senior Scientist, Protein Science

Bonum Therapeutics, Inc. is an early-stage biotech company creating a new class of immuno-oncology protein therapeutics that are delivered systemically but activated locally.

We are seeking a senior scientist to join our growing team.  As part of a well-supported and integrated group, the individual will help drive our strategy to purify and characterize novel antibody-like proteins and advance our drugs into the clinic. The ideal candidate is a rigorous and hardworking scientist, highly organized and detail-oriented. The ability to contribute to a team effort is critical.  We prize diversity, and welcome applicants from both industry and academia.

Our Seattle labs are in the bustling biotech center of South Lake Union/Eastlake. We offer competitive salaries, generous equity participation and excellent benefits.  

Responsibilities:

• Manage a team of scientists to purify and characterize various recombinant proteins (antibodies, Fc-fusion proteins, bispecific-like formats, etc.) to support multiple ongoing preclinical programs
• Analyze protein production and analytical data, drive strategies for achieving desired mass and quality in a timely manner
• Employ a variety of biophysical techniques to characterize protein quality and stability during storage and use
• Review purification data in electronic notebook entries for completeness and accuracy
• Coordinate purification activities with mol/bio expression lead and supervisor
• Communicate with staff members in other functional areas regarding status of critical reagents
• Explore new technologies for protein production and characterization
• Implement approaches for higher throughput protein purification

Requirements

• BS/MS with 12+ years of experience, or PhD with 5+ years with significant experience purifying antibody-based formats using affinity and traditional chromatography methods
• Previous supervisory experience, including setting priorities, scheduling activities and enabling career development opportunities for staff members
• Significant experience with Cytiva AKTA preparative chromatography platforms and Agilent HPLC systems in the purification of proteins
• Experience performing and analyzing results of SDS-PAGE, Western blot, IEF, DSF, and UV-Vis spectrophotometry and other common protein analysis techniques
• Solid understanding of protein structure, impact of charge, hydrophobicity, etc. on solubility and stability
• Ability to work efficiently and independently in a dynamic team environment
• Attentive to details and able to contribute effectively as part of a team.
• Excellent record keeping and communication skills
• Enthusiasm to learn and to develop new methods

The annual salary range for the position is $140k - $170k. Job level and compensation will depend on the qualifications of the final candidate.

Benefits

• Medical, Dental, Vision, Rx (premiums fully paid for employees and covered dependents)
• Funded HSA
• 401(k) with company match
• Life insurance, short-term & long-term disability insurance
• Generous PTO and paid holidays
• Wellness Resources
• Generous equity (new hire and ongoing stock option grants)
• Training & development opportunities
• Commuter benefit (ORCA Passport), parking