Downstream Manufacturing Supervisor
Global Life Science Hub
Chicago, illinois
Job Details
Full-time
Full Job Description
The Downstream Manufacturing Supervisor is a hands-on position responsible for executing purification of mammalian cell-based cultures and producing recombinant proteins for a wide range of mammalian based biosimilars. The candidate will be responsible in the purification of 50L to 1000L volumes engineering, clinical and commercial batches in a cGMP environment. This position requires technical expertise in AKTA purification skids or similar, TFF and knowledge of initiating batch records, protocols, investigations and other technical documents.
Work in a team environment to execute batches and can work independently with minimum supervision. This position requires extensive technical expertise in mammalian cell-based purification processes, cGMP manufacturing and compliance for BLA requirements.
Responsibilities:
- Perform and supervise downstream process at multiple scales in a cGMP environment, column packing, process troubleshooting and data analysis.
- Provides technical direction in the execution and development of the purification process.
- Uses programs to collect and evaluate operating data to conduct on line adjustments to products, instruments or equipment.
- Prepare/ review all quality management related documents (Deviation / Change control / investigation reports etc.)
- Ensure that engineering and clinical batches are executed in a timely manner.
- Establishes operating equipment specifications and improves manufacturing techniques.
- Works with other teams and outside vendors to resolve technical issues as well as maintenance of production equipment.
- Should follow GMP instructions in the manufacturing area and take the lead to follow environmental health and safety policies.
- Coordinate the conduction of investigations and corrections for issues found during the batch execution process.
- Performs other functions as required or assigned.
- Complies with all company policies and standards.
Requirements:
- Requires a Bachelor or Master’ degree in chemical, biological or biochemical sciences and a minimum of 7 - 10 years of related experience in the biopharmaceutical industry.
- Previous experience working in GMP and aseptic manufacturing environment.
- Experience working with AKTA Process skids or similar and familiarity of single use manufacturing consumables such as bags, tube sets, columns and process manifolds.
- Possess knowledge to execute engineering and clinical batches; familiar with GMP documentation.
Apply
Global Life Science Hub is a specialized Life Science headhunting firm. We place professionals across the United States and Europe for various Biotechnology, Pharmaceutical, and CDMO companies, ranging from small start-ups to large global organizations.
If you’re interested, please apply below. If this position doesn’t suit you, visit our website for more vacancies – www.glshub.com